- Herpes simplex virus infections can be associated with large genital and perirectal lesions, esophagitis, proctitis, and pulmonary disease.
- HIV-infected individuals are more likely to have severe diseases and treatment failures due to the development of resistance.
- Administration of acyclovir (400 mg PO tid), famciclovir (250 mg PO tid), or valacyclovir (500 mg PO tid) for 1 week is usually effective. For more severe disease, IV acyclovir, 5 mg/kg q8h, is recommended.
- Relapses are frequent, and acyclovir, 400 mg PO bid, may prevent their recurrence.
- Herpes simplex virus can become resistant to acyclovir, in which case foscarnet, 40 mg/kg IV q8h for 10â??14 days, or one dose of cidofovir, 5 mg/kg IV, should be used.