- This infection can involve the lungs, CNS, heart, kidneys, and sinuses.
- Aspergillosis is increasing among HIV-infected patients, especially those who are neutropenic and those with advanced disease (<50 CD4 cells/microliter).
- Diagnosis requires a biopsy of the tissue involved.
- Voriconazole is the treatment of choice.
- Alternatives include amphotericin B and itraconazole.
- Caspofungin can be used for refractory disease using an induction dose of 70 mg IV the first day and subsequently 50 mg IV daily for maintenance.
- Combination therapy is under study. Prognosis is poor for patients with invasive aspergillosis.